Details for gene set MAPKKK_CASCADE_GO

Table: GSEA Results Summary

Dataset	GSEAGood_collapsed_to_symbols.cls2class
Phenotype	cls2class.cls
Upregulated in class	Metastatic
GeneSet	MAPKKK_CASCADE_GO_0000165
Enrichment Score (ES)	0.4104747
Normalized Enrichment Score (NES)	1.5213077
Nominal p-value	0.0
FDR q-value	0.47030717
FWER p-Value	1.0

Table: GSEA details [plain text format]
	PROBE	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	MAPK8IP1	MAPK8IP1 Entrez, Source	mitogen-activated protein kinase 8 interacting protein 1	30	1.423	0.0474	Yes
2	CAMKK2	CAMKK2 Entrez, Source	calcium/calmodulin-dependent protein kinase kinase 2, beta	86	1.168	0.0830	Yes
3	CXCR4	CXCR4 Entrez, Source	chemokine (C-X-C motif) receptor 4	90	1.163	0.1241	Yes
4	SOD1	SOD1 Entrez, Source	superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult))	136	1.077	0.1576	Yes
5	MAP3K9	MAP3K9 Entrez, Source	mitogen-activated protein kinase kinase kinase 9	277	0.910	0.1745	Yes
6	DUSP8	DUSP8 Entrez, Source	dual specificity phosphatase 8	422	0.808	0.1873	Yes
7	DAXX	DAXX Entrez, Source	death-associated protein 6	424	0.807	0.2160	Yes
8	MAP3K11	MAP3K11 Entrez, Source	mitogen-activated protein kinase kinase kinase 11	535	0.750	0.2306	Yes
9	CD24	CD24 Entrez, Source	CD24 molecule	648	0.701	0.2432	Yes
10	MAPK8IP3	MAPK8IP3 Entrez, Source	mitogen-activated protein kinase 8 interacting protein 3	667	0.693	0.2659	Yes
11	ADRB2	ADRB2 Entrez, Source	adrenergic, beta-2-, receptor, surface	705	0.676	0.2859	Yes
12	MAPK8IP2	MAPK8IP2 Entrez, Source	mitogen-activated protein kinase 8 interacting protein 2	769	0.652	0.3021	Yes
13	HIPK2	HIPK2 Entrez, Source	homeodomain interacting protein kinase 2	780	0.649	0.3242	Yes
14	MAP3K13	MAP3K13 Entrez, Source	mitogen-activated protein kinase kinase kinase 13	781	0.648	0.3473	Yes
15	DUSP10	DUSP10 Entrez, Source	dual specificity phosphatase 10	864	0.617	0.3602	Yes
16	MAP4K2	MAP4K2 Entrez, Source	mitogen-activated protein kinase kinase kinase kinase 2	956	0.587	0.3711	Yes
17	MADD	MADD Entrez, Source	MAP-kinase activating death domain	1058	0.559	0.3798	Yes
18	PKN1	PKN1 Entrez, Source	protein kinase N1	1218	0.515	0.3805	Yes
19	MINK1	MINK1 Entrez, Source	misshapen-like kinase 1 (zebrafish)	1907	0.391	0.3182	Yes
20	ADRB3	ADRB3 Entrez, Source	adrenergic, beta-3-, receptor	1934	0.387	0.3291	Yes
21	GADD45G	GADD45G Entrez, Source	growth arrest and DNA-damage-inducible, gamma	2023	0.373	0.3327	Yes
22	MAP3K5	MAP3K5 Entrez, Source	mitogen-activated protein kinase kinase kinase 5	2074	0.365	0.3402	Yes
23	DUSP9	DUSP9 Entrez, Source	dual specificity phosphatase 9	2088	0.363	0.3517	Yes
24	DUSP6	DUSP6 Entrez, Source	dual specificity phosphatase 6	2111	0.359	0.3620	Yes
25	AMBP	AMBP Entrez, Source	alpha-1-microglobulin/bikunin precursor	2114	0.358	0.3746	Yes
26	MAP3K10	MAP3K10 Entrez, Source	mitogen-activated protein kinase kinase kinase 10	2176	0.348	0.3802	Yes
27	PIK3CB	PIK3CB Entrez, Source	phosphoinositide-3-kinase, catalytic, beta polypeptide	2239	0.340	0.3855	Yes
28	RGS4	RGS4 Entrez, Source	regulator of G-protein signalling 4	2422	0.315	0.3765	Yes
29	MAPKAPK2	MAPKAPK2 Entrez, Source	mitogen-activated protein kinase-activated protein kinase 2	2606	0.293	0.3667	Yes
30	RGS3	RGS3 Entrez, Source	regulator of G-protein signalling 3	2609	0.292	0.3769	Yes
31	MDFI	MDFI Entrez, Source	MyoD family inhibitor	2626	0.290	0.3854	Yes
32	DUSP2	DUSP2 Entrez, Source	dual specificity phosphatase 2	2630	0.290	0.3954	Yes
33	C5	C5 Entrez, Source	complement component 5	2662	0.286	0.4022	Yes
34	TPD52L1	TPD52L1 Entrez, Source	tumor protein D52-like 1	2680	0.284	0.4105	Yes
35	REN	REN Entrez, Source	renin	2894	0.260	0.3961	No
36	CRKL	CRKL Entrez, Source	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	3336	0.213	0.3549	No
37	MAPK8	MAPK8 Entrez, Source	mitogen-activated protein kinase 8	3422	0.203	0.3527	No
38	MAP2K7	MAP2K7 Entrez, Source	mitogen-activated protein kinase kinase 7	3572	0.185	0.3428	No
39	TAOK2	TAOK2 Entrez, Source	TAO kinase 2	3755	0.168	0.3286	No
40	MAP4K1	MAP4K1 Entrez, Source	mitogen-activated protein kinase kinase kinase kinase 1	3969	0.142	0.3100	No
41	FPR1	FPR1 Entrez, Source	formyl peptide receptor 1	4010	0.138	0.3105	No
42	TGFA	TGFA Entrez, Source	transforming growth factor, alpha	4160	0.125	0.2985	No
43	MAP4K5	MAP4K5 Entrez, Source	mitogen-activated protein kinase kinase kinase kinase 5	4511	0.088	0.2628	No
44	ADRA2A	ADRA2A Entrez, Source	adrenergic, alpha-2A-, receptor	4597	0.078	0.2562	No
45	NF1	NF1 Entrez, Source	neurofibromin 1 (neurofibromatosis, von Recklinghausen disease, Watson disease)	5252	0.010	0.1841	No
46	SPRED2	SPRED2 Entrez, Source	sprouty-related, EVH1 domain containing 2	5285	0.006	0.1807	No
47	TDGF1	TDGF1 Entrez, Source	teratocarcinoma-derived growth factor 1	5318	0.003	0.1773	No
48	FGFR3	FGFR3 Entrez, Source	fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism)	5352	-0.001	0.1737	No
49	EGF	EGF Entrez, Source	epidermal growth factor (beta-urogastrone)	5507	-0.017	0.1572	No
50	SCG2	SCG2 Entrez, Source	secretogranin II (chromogranin C)	5534	-0.021	0.1551	No
51	ADORA2B	ADORA2B Entrez, Source	adenosine A2b receptor	5572	-0.025	0.1519	No
52	NRTN	NRTN Entrez, Source	neurturin	5699	-0.042	0.1394	No
53	MAP3K12	MAP3K12 Entrez, Source	mitogen-activated protein kinase kinase kinase 12	5781	-0.051	0.1322	No
54	TAOK3	TAOK3 Entrez, Source	TAO kinase 3	5814	-0.055	0.1306	No
55	MAPK9	MAPK9 Entrez, Source	mitogen-activated protein kinase 9	6077	-0.091	0.1048	No
56	GADD45B	GADD45B Entrez, Source	growth arrest and DNA-damage-inducible, beta	6279	-0.117	0.0867	No
57	CD81	CD81 Entrez, Source	CD81 molecule	6468	-0.146	0.0711	No
58	MAP3K3	MAP3K3 Entrez, Source	mitogen-activated protein kinase kinase kinase 3	6641	-0.170	0.0581	No
59	DUSP4	DUSP4 Entrez, Source	dual specificity phosphatase 4	6689	-0.177	0.0592	No
60	SHC1	SHC1 Entrez, Source	SHC (Src homology 2 domain containing) transforming protein 1	6758	-0.189	0.0584	No
61	MAP3K4	MAP3K4 Entrez, Source	mitogen-activated protein kinase kinase kinase 4	6759	-0.189	0.0652	No
62	ATP6AP2	ATP6AP2 Entrez, Source	ATPase, H+ transporting, lysosomal accessory protein 2	6972	-0.232	0.0499	No
63	GRM4	GRM4 Entrez, Source	glutamate receptor, metabotropic 4	7125	-0.267	0.0426	No
64	FGFR1	FGFR1 Entrez, Source	fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)	7153	-0.273	0.0494	No
65	ADRA2C	ADRA2C Entrez, Source	adrenergic, alpha-2C-, receptor	7232	-0.293	0.0512	No
66	TNIK	TNIK Entrez, Source	TRAF2 and NCK interacting kinase	7280	-0.306	0.0569	No
67	FGF2	FGF2 Entrez, Source	fibroblast growth factor 2 (basic)	7369	-0.331	0.0589	No
68	MAP2K4	MAP2K4 Entrez, Source	mitogen-activated protein kinase kinase 4	7599	-0.393	0.0475	No
69	MAPK10	MAPK10 Entrez, Source	mitogen-activated protein kinase 10	7664	-0.412	0.0551	No
70	FGF13	FGF13 Entrez, Source	fibroblast growth factor 13	7684	-0.419	0.0680	No
71	PLCE1	PLCE1 Entrez, Source	phospholipase C, epsilon 1	7996	-0.517	0.0519	No
72	MDFIC	MDFIC Entrez, Source	MyoD family inhibitor domain containing	8081	-0.546	0.0621	No
73	CARTPT	CARTPT Entrez, Source	CART prepropeptide	8187	-0.590	0.0715	No
74	PAK1	PAK1 Entrez, Source	p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)	8544	-0.814	0.0611	No